About Astadol Tablet 37.5 / 325mg
Astadol Tablet relieves moderate to severe pain using Tramadol and Paracetamol combination.
Astadol Tablet Uses
- Relieves moderate to moderately severe pain after injury or surgery.
- Manages chronic musculoskeletal pain such as back pain and osteoarthritis.
- Used for short term relief of acute pain when simple analgesics are not enough.
- Helps control dental and post procedure pain under medical guidance.
Astadol Tablet Benefits
- Combines two complementary painkillers for faster, more complete relief.
- Lower tramadol dose per tablet can reduce some opioid related side effects.
- Paracetamol component adds fever reducing action alongside pain relief.
- Useful when single agent painkillers fail to control moderate pain.
What Experts Say
Tramadol acts on opioid receptors in the brain and spinal cord while also affecting serotonin and norepinephrine pathways in the central nervous system. This dual action makes it effective for pain that does not respond well to paracetamol alone, but it also explains why tramadol carries a seizure risk and interacts with certain antidepressants.
Combining tramadol with paracetamol allows doctors to use a lower tramadol dose while still achieving strong pain relief. This combination approach can reduce some opioid related side effects compared to using tramadol alone at a higher dose for the same level of pain control.
Because tramadol carries dependence and misuse potential, prescribers in Pakistan treat it as a controlled substance and limit prescriptions to the shortest effective duration. Long term use needs medical supervision to watch for tolerance, dependence, withdrawal symptoms and organ function.
Drug Class
- Opioid analgesic combination
- Centrally acting analgesic
Astadol Tablet 37.5 / 325mg Uses in Urdu
- درمیانے سے شدید درد میں آرام کے لیے استعمال ہوتی ہے
- آپریشن کے بعد ہونے والے درد میں مفید ہے
- پٹھوں اور ہڈیوں کے درد میں استعمال ہوتی ہے
- ڈاکٹر کی ہدایت کے مطابق طویل مدتی درد کے علاج میں شامل ہے
Astadol Tablet 37.5 / 325mg formula
- Tramadol Hydrochloride + Paracetamol
How to use Astadol Tablet 37.5 / 325mg?
- Take exactly as prescribed by your doctor, usually every 4 to 6 hours as needed for pain.
- Do not exceed the maximum dose advised by your physician in 24 hours.
- Swallow the tablet whole with water, with or without food.
- Do not crush, break or chew the tablet.
- Avoid alcohol while taking this medicine.
- Do not stop suddenly after prolonged use, taper off under medical supervision.
Drug Interactions
- SSRIs And SNRIs: Combining with antidepressants such as sertraline or venlafaxine raises the risk of serotonin syndrome.
- MAO Inhibitors: Concurrent use can cause a dangerous serotonin syndrome and is generally avoided.
- Other Opioids And Sedatives: Combining with benzodiazepines or other opioids increases the risk of severe sedation and respiratory depression.
- Warfarin: Tramadol can enhance the effect of warfarin and increase bleeding risk.
- Carbamazepine: Reduces tramadol effectiveness and increases seizure risk.
- Alcohol: Increases sedation and the risk of respiratory depression.
Risks and warnings
- Controlled Substance Status: Tramadol is a regulated opioid analgesic in Pakistan and requires a valid doctor prescription.
- Seizure Risk: Tramadol can lower the seizure threshold, use with caution in patients with epilepsy or head injury.
- Dependence And Abuse Potential: Prolonged use can lead to physical dependence and withdrawal symptoms on stopping.
- Respiratory Depression: High doses or use with other sedatives can slow or stop breathing, especially in elderly or debilitated patients.
- Serotonin Syndrome: Risk increases when combined with other serotonergic drugs such as antidepressants.
- Liver Impairment: The paracetamol component can cause liver damage in overdose or with existing liver disease.
Astadol Tablet Side Effects
- Nausea
- Vomiting
- Dizziness
- Constipation
- Drowsiness
- Dry mouth
- Sweating
- Headache
- Rare seizures, especially at high doses
- Rare serotonin syndrome when combined with other serotonergic drugs
- Rare severe allergic reaction with swelling or difficulty breathing
- Rare severe skin reaction or liver injury linked to the paracetamol component
Storage Conditions
- Store at room temperature below 25 degrees Celsius.
- Keep away from heat, moisture and direct light.
- Store in a secure place away from children due to its controlled substance status.
- Dispose of unused tablets safely and do not share with others.
