Exval-A Tablet 5mg / 80mg

About Exval-A Tablet 5mg / 80mg

Exval-A Tablet 5mg / 80mg Uses

• Treatment of essential hypertension in adults
• Used when blood pressure is not controlled by a single antihypertensive agent
• Long term blood pressure management in patients with added cardiovascular risk factors

Exval-A Tablet 5mg / 80mg Benefits

• Combines two complementary mechanisms for stronger blood pressure control
• Reduces the workload on the heart and blood vessels
• Once daily dosing improves treatment adherence
• Lower dose combination reduces the chance of dose dependent side effects seen with higher single agent doses

What Experts Say

Exval-A combines amlodipine, a calcium channel blocker, with valsartan, an angiotensin receptor blocker. Amlodipine relaxes blood vessel walls by blocking calcium entry into smooth muscle cells, while valsartan blocks the action of angiotensin II, a hormone that narrows blood vessels and raises blood pressure.

Using both mechanisms together produces a more consistent blood pressure reduction than either drug alone, since they act on separate pathways. This combination approach also allows doctors to use lower doses of each component, which can reduce dose related side effects such as ankle swelling.

Doctors typically prescribe this fixed dose combination once blood pressure control with a single agent has not reached target levels. Regular monitoring of blood pressure, kidney function and electrolyte levels is recommended during treatment, since the combination affects both vascular tone and kidney handling of sodium and potassium.

Drug Class

• Calcium channel blocker combined with angiotensin receptor blocker
• Antihypertensive combination therapy

Exval-A Tablet 5mg / 80mg formula

• Amlodipine + Valsartan

Available forms

• Tablet

How to use Exval-A Tablet 5mg / 80mg?

• Take one tablet daily at the same time, with or without food
• Swallow the tablet whole with a glass of water
• Do not crush or chew the tablet
• Continue taking the medicine even if blood pressure feels normal, unless advised otherwise
• Do not stop the medicine abruptly without consulting a doctor

Drug Interactions

• Potassium Sparing Diuretics: Combining these with valsartan can raise blood potassium to unsafe levels.
• NSAIDs: Regular use of nonsteroidal anti-inflammatory drugs can reduce the blood pressure lowering effect and affect kidney function.
• Simvastatin: High dose simvastatin combined with amlodipine increases the risk of muscle related side effects.
• Other Antihypertensives: Using Exval-A with other blood pressure medicines can increase the risk of excessive blood pressure lowering.
• Lithium: Valsartan can increase lithium levels in the blood, raising the risk of lithium toxicity.

Risks and warnings

• Low Blood Pressure: Exval-A can cause symptomatic hypotension, especially after the first dose or in patients who are volume depleted.
• Peripheral Edema: Amlodipine commonly causes swelling of the ankles and feet, which can be more noticeable at higher doses.
• Pregnancy Risk: Valsartan can cause fetal injury and death when used during the second and third trimesters, so this medicine must be avoided in pregnancy.
• Kidney Function: Patients with kidney artery narrowing or reduced kidney function need monitoring, since valsartan can affect kidney function and potassium levels.
• Elevated Potassium: Valsartan can raise blood potassium levels, particularly when combined with potassium sparing diuretics or supplements.

Exval-A Tablet 5mg / 80mg Side Effects

• Swelling of the ankles or feet
• Dizziness
• Headache
• Fatigue
• Flushing
• Low blood pressure
• Palpitations
• Nausea
• Upper respiratory infection symptoms
• Elevated potassium levels
• Reduced kidney function in susceptible patients
• Allergic skin reactions in rare cases

Storage Conditions

• Store below 30°C in a dry place away from moisture
• Keep the tablet in its original packaging until use
• Protect from direct heat and sunlight
• Keep out of reach of children