Glyrate SR Tablet 6.4mg

About Glyrate SR Tablet 6.4mg

Glyrate SR Tablet 6.4mg Uses

• Prevention of angina pectoris (chest pain) in patients with coronary artery disease
• Long term maintenance therapy after initial nitrate dose titration
• Reducing frequency and severity of exertional angina episodes
• Adjunct therapy in chronic ischemic heart disease management

Glyrate SR Tablet 6.4mg Benefits

• Extended, steady release keeps nitrate levels stable over several hours
• Fewer daily doses compared to immediate release nitrate tablets
• Helps patients stay active with less exertional chest discomfort
• Supports higher dose maintenance once lower doses are already tolerated

What Experts Say

Cardiologists describe glyceryl trinitrate as an organic nitrate that the body converts into nitric oxide. This relaxes smooth muscle in blood vessel walls, widening veins more than arteries. The result is reduced blood return to the heart, lower cardiac workload, and less oxygen demand during physical exertion.

Physicians generally reserve the 6.4mg strength for patients who have already tolerated lower nitrate doses without significant headache or dizziness. A daily nitrate free interval of eight to twelve hours is recommended to prevent tolerance, where the medicine gradually loses its protective effect with continuous exposure.

Experts caution that sustained release nitroglycerin treats chronic angina prevention, not sudden chest pain attacks, which still need fast acting sublingual nitrate. Regular blood pressure checks and reporting persistent headache, fainting, or worsening chest pain to a doctor remain part of safe long term use.

Drug Class

• Organic Nitrate
• Antianginal Agent
• Vasodilator

Glyrate SR Tablet 6.4mg formula

• Glyceryl Trinitrate

Available forms

• Tablet

How to use Glyrate SR Tablet 6.4mg?

• Swallow the tablet whole with a glass of water
• Do not crush, chew, or break the sustained release tablet
• Take at the same times each day as advised by your doctor
• Follow the prescribed nitrate free interval to avoid reduced effect
• Do not stop the medicine suddenly without medical advice

Drug Interactions

• Sildenafil, Tadalafil, Vardenafil: Combination can cause severe, life threatening low blood pressure
• Riociguat: Contraindicated together due to added blood pressure lowering effect
• Other Blood Pressure Medicines: May intensify the blood pressure lowering effect
• Alcohol: Increases risk of dizziness and fainting
• Aspirin: May increase nitroglycerin blood levels slightly, monitor for headache or hypotension

Risks and warnings

• Low Blood Pressure: May cause a sudden drop in blood pressure, especially when standing up quickly
• Severe Headache: Common at the start of treatment due to blood vessel widening in the head
• PDE5 Inhibitor Use: Never combine with sildenafil, tadalafil, or vardenafil, this can cause dangerously low blood pressure
• Heart Conditions: Use with caution in hypertrophic cardiomyopathy or severe aortic stenosis
• Pregnancy And Breastfeeding: Use only if the treating doctor confirms it is necessary
• Alcohol: Avoid alcohol, it can worsen low blood pressure and dizziness

Glyrate SR Tablet 6.4mg Side Effects

• Headache, often throbbing, especially in early treatment days
• Dizziness or lightheadedness on standing
• Flushing of the face and neck
• Low blood pressure
• Fast heartbeat or palpitations
• Nausea
• Fainting in severe cases of blood pressure drop
• Skin rash in rare allergic reactions

Storage Conditions

• Store below 25°C in a cool, dry place
• Keep the container tightly closed to prevent loss of potency
• Protect from direct light and moisture
• Keep out of reach of children
• Discard any unused tablets after the expiry date