Klevra Tablet 250mg

About Klevra Tablet 250mg

Klevra Tablet 250mg Uses

• Partial onset seizures in adults and children
• Myoclonic seizures in juvenile myoclonic epilepsy
• Primary generalized tonic-clonic seizures
• Add on therapy alongside other anti-epileptic drugs

Klevra Tablet 250mg Benefits

• Reduces the frequency of seizures over time
• Twice daily dosing helps maintain steady seizure control
• Fewer drug interactions compared with many older anticonvulsants
• Can be started at a low dose and adjusted gradually for tolerance

What Experts Say

Levetiracetam works differently from older anticonvulsants. It binds to synaptic vesicle protein SV2A in the brain, which modulates neurotransmitter release and dampens the abnormal, repetitive neuronal firing that underlies seizures, rather than blocking sodium or calcium channels directly.

This distinct mechanism means levetiracetam has few interactions tied to liver enzyme induction, since it is largely cleared unchanged by the kidneys. Clinical studies support its use as add on therapy for partial onset seizures and as monotherapy in several seizure types, with dose usually titrated upward over two week intervals.

Behavioral and mood changes are a recognized class effect of anticonvulsants including levetiracetam, so clinicians monitor for irritability or low mood, especially early in treatment. Kidney function also guides dosing, since reduced renal clearance requires a lower daily dose to avoid drug accumulation.

Drug Class

• Anticonvulsant (Antiepileptic Drug)
• Synaptic Vesicle Protein 2A (SV2A) Ligand
• Pyrrolidone Derivative

Klevra Tablet 250mg formula

• Levetiracetam

Available forms

• Tablet

How to use Klevra Tablet 250mg?

• Take Klevra Tablet 250mg exactly as prescribed, usually twice daily at evenly spaced times.
• Swallow the tablet whole with water, with or without food.
• Do not stop the medicine suddenly, since this can trigger seizures.
• Take the missed dose as soon as remembered, unless the next dose is near.
• Keep taking the medicine even if seizures are well controlled, unless the doctor advises otherwise.

Drug Interactions

• Other Anticonvulsants: Combined use may increase drowsiness and coordination problems, though pharmacokinetic interactions are minimal.
• Alcohol and Sedatives: These add to the drowsiness and dizziness caused by levetiracetam.
• Oral Contraceptives: Levetiracetam does not significantly reduce their effectiveness, unlike many older anticonvulsants.
• Methotrexate: Levetiracetam clearance may be reduced when given with methotrexate, raising levetiracetam levels.

Risks and warnings

• Mood and Behavior Changes: May cause irritability, agitation or low mood, and rarely thoughts of self harm.
• Sudden Withdrawal: Stopping the medicine abruptly can cause seizures to return or worsen.
• Kidney Function: Dose needs adjustment in patients with reduced kidney function, since the drug is cleared mainly by the kidneys.
• Pregnancy: Should be used only if clearly needed, under specialist supervision, as it crosses the placenta.
• Driving and Machinery: May cause drowsiness or dizziness, so caution is needed with driving until effects are known.

Klevra Tablet 250mg Side Effects

• Drowsiness or fatigue
• Dizziness or unsteady walking
• Headache
• Loss of appetite
• Irritability or mood changes
• Nasal congestion
• Double vision
• Signs of infection such as fever or sore throat
• Severe skin rash with fever and swollen glands
• Thoughts of self harm, which need urgent medical attention

Storage Conditions

• Store below 30°C in a cool, dry place away from direct light.
• Keep the tablets in their original strip or container.
• Keep out of reach of children.
• Do not use the tablets after the expiry date on the pack.