Klevra Tablet 500mg

About Klevra Tablet 500mg

Klevra Tablet 500mg Uses

• Partial onset seizures in adults and children with epilepsy
• Myoclonic seizures in juvenile myoclonic epilepsy
• Primary generalized tonic clonic seizures
• Add on therapy alongside other antiepileptic drugs

Klevra Tablet 500mg Benefits

• Works quickly with a simple twice daily dosing schedule
• Minimal interaction with other medicines since it skips liver enzyme pathways
• Suitable for long term seizure control with a good safety record
• Available as tablet and injection for flexible treatment options

What Experts Say

Levetiracetam binds to synaptic vesicle protein 2A (SV2A) in the brain, a mechanism distinct from older anticonvulsants that act on sodium channels or GABA receptors. This binding modulates neurotransmitter release at nerve terminals, reducing the abnormal, repetitive neuronal firing that triggers seizures.

Its pharmacokinetic profile appeals to prescribing physicians because absorption is rapid and near complete, protein binding is minimal, and the drug undergoes almost no hepatic metabolism. Around two thirds is excreted unchanged by the kidneys, which limits the drug interaction risk that complicates many combination epilepsy regimens.

Neurologists often choose levetiracetam as add on or monotherapy for partial onset and generalized seizures because dose titration is straightforward and the therapeutic window is wide. Renal function still needs monitoring since dose adjustment is required in kidney impairment, and mood or behavioral changes are watched for during early treatment.

Drug Class

• Antiepileptic (anticonvulsant)
• Pyrrolidone derivative
• SV2A ligand

Klevra Tablet 500mg formula

• Levetiracetam

Available forms

• Tablet

How to use Klevra Tablet 500mg?

• Take Klevra Tablet 500mg exactly as prescribed by your doctor, usually twice a day
• Swallow the tablet whole with a glass of water, with or without food
• Do not stop the medicine suddenly, dose is usually reduced gradually
• Take doses about 12 hours apart to keep a steady level in the blood
• A missed dose should be taken as soon as remembered unless it is close to the next dose

Drug Interactions

• Other Antiepileptic Drugs: Combining with other seizure medicines can increase drowsiness and sedation.
• Alcohol: Increases central nervous system depression and dizziness.
• Sedatives Or Sleep Aids: Additive drowsiness may occur when taken together.
• Methotrexate: May raise levetiracetam blood levels by affecting kidney clearance.
• Oral Contraceptives: Levetiracetam does not reduce their effectiveness, unlike many older antiepileptics.

Risks and warnings

• Mood Changes: May cause irritability, agitation, depression or rare suicidal thoughts, report any mood change to your doctor promptly.
• Pregnancy: Use only if clearly needed, discuss risks and benefits with your doctor before and during pregnancy.
• Kidney Impairment: Dose adjustment is required in patients with reduced kidney function.
• Driving And Machinery: May cause drowsiness or dizziness, avoid driving until you know how the tablet affects you.
• Sudden Discontinuation: Stopping abruptly can trigger rebound seizures, taper the dose under medical supervision.

Klevra Tablet 500mg Side Effects

• Drowsiness and fatigue
• Dizziness
• Headache
• Irritability or mood swings
• Loss of appetite
• Nasal congestion or upper respiratory infection
• Weakness
• Behavioral changes including aggression or anxiety
• Rare severe skin reactions
• Rare blood cell count changes

Storage Conditions

• Store below 30°C in a cool dry place away from direct sunlight
• Keep the tablet strip in its original packaging until ready to use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack