Lezra Tablet 2.5mg

About Lezra Tablet 2.5mg

Lezra Tablet Uses

• Hormone receptor positive breast cancer treatment in postmenopausal women
• First line or extended adjuvant hormonal therapy after breast cancer surgery
• Off label ovulation induction in women with PCOS related infertility
• Selected cases of unexplained infertility under fertility specialist care

Lezra Tablet Benefits

• Estrogen lowering effect that slows growth of hormone sensitive breast tumors
• Reduced risk of cancer recurrence with long term adjuvant therapy use
• A lower cost ovulation induction option compared to injectable fertility drugs
• Higher live birth rates than clomiphene in PCOS related infertility according to major fertility trials

What Experts Say

Letrozole works by blocking the aromatase enzyme that converts androgens into estrogen in body tissue. In postmenopausal women, this is the main source of circulating estrogen, and hormone receptor positive breast tumors depend on this estrogen to grow. By lowering estrogen levels, letrozole slows or stops tumor growth.

Large clinical trials have shown letrozole reduces the risk of breast cancer recurrence compared to tamoxifen when used as initial or extended adjuvant therapy in postmenopausal women. Oncologists typically prescribe it for five years or longer, with regular monitoring of bone density and cholesterol since estrogen suppression affects both.

In reproductive medicine, letrozole is used off label to trigger ovulation in women with polycystic ovary syndrome. Research comparing it with clomiphene citrate found higher ovulation and live birth rates with letrozole in this group. Because it directly lowers estrogen, treatment cycles need ultrasound monitoring by a fertility specialist to track follicle growth safely.

Drug Class

• Aromatase inhibitor (nonsteroidal)
• Hormonal anticancer agent
• Ovulation inducing agent (off label use)

Lezra Tablet 2.5mg formula

• Letrozole

Available forms

• Tablet

How to use Lezra Tablet 2.5mg?

• Prescribed dose taken exactly as directed by your oncologist or gynecologist
• One tablet swallowed whole with a full glass of water
• Same time every day when used for breast cancer treatment
• A specific cycle day schedule when used for ovulation induction, as set by your doctor
• No missed doses or early stopping without medical advice
• A negative pregnancy test confirmed before starting each new treatment cycle

Drug Interactions

• Tamoxifen: Combined use with Lezra Tablet may lower letrozole levels and reduce its effectiveness, so doctors avoid this combination.
• Estrogen containing medicines: Hormonal contraceptives or hormone replacement therapy can directly counteract the estrogen lowering effect of Lezra Tablet.
• Other aromatase inhibitors: Concurrent use with drugs like anastrozole or exemestane is not recommended since they work through the same pathway.
• Fertility injections: Concurrent use of gonadotropins for ovulation induction requires careful specialist dosing to avoid overstimulation.

Risks and warnings

• Pregnancy risk: Lezra Tablet can cause fetal harm and must never be taken during pregnancy or while trying to conceive without medical supervision.
• Bone loss: Long term use lowers estrogen and can reduce bone density, raising fracture risk over time.
• Cardiovascular effects: The tablet can raise cholesterol levels and has been linked to a higher risk of heart related events in some patients.
• Liver impairment: Patients with significant liver disease need dose adjustment and closer monitoring.
• Specialist supervision: This is a high risk hormonal medicine and should only be used under an oncologist or gynecologist's direct supervision.
• Limited approved population: Lezra Tablet is approved for breast cancer treatment only in postmenopausal women.

Lezra Tablet Side Effects

• Hot flashes and night sweats
• Joint pain and muscle stiffness
• Fatigue and general weakness
• Nausea
• Headache and dizziness
• Hair thinning
• Weight changes
• Mood swings or low mood
• Vaginal dryness
• Bone pain with long term use
• Chest pain or shortness of breath (seek immediate care)
• Signs of blood clots such as leg swelling or sudden pain (seek immediate care)

Storage Conditions

• Store Lezra Tablet at room temperature between 15 and 30 degrees Celsius
• Keep the tablet in its original blister pack away from light
• Protect it from moisture and store in a dry place
• Keep it out of reach of children
• Discard any expired tablets safely and do not reuse them