Mefenamic Acid tablet 250mg

About Mefenamic Acid tablet 250mg

Mefenamic Acid Tablet 250mg Uses

• Relieves menstrual pain (dysmenorrhea)
• Eases headache and migraine related pain
• Reduces dental pain after procedures
• Treats mild to moderate muscle and joint pain
• Helps lower fever
• Used for general mild to moderate pain relief after minor injuries or surgery

What Experts Say

Mefenamic acid belongs to the fenamate group of NSAIDs. It works by blocking the cyclooxygenase enzymes that produce prostaglandins in the body. Prostaglandins are chemicals that trigger pain, inflammation and uterine contractions, which is why this medicine works especially well for menstrual cramps.

Doctors in Pakistan often recommend mefenamic acid for period pain because it targets the prostaglandin surge that causes strong uterine contractions during the first days of a cycle. Taking it with food helps reduce stomach irritation, and starting the dose at the first sign of pain usually gives better relief than waiting for pain to peak.

Since mefenamic acid is an NSAID, doctors weigh its full risk profile before recommending regular or prolonged use. Extended use can affect the stomach lining, put strain on the kidneys, and raise cardiovascular risk in people with existing heart conditions. Physicians in Pakistan generally limit use to short courses at the lowest effective dose and review a patient's kidney function, blood pressure and heart history before advising long term use.

Mefenamic Acid tablet 250mg formula

• Mefenamic Acid

Available forms

• Tablet
• Suspension

How to use Mefenamic Acid tablet 250mg?

• Take Mefenamic Acid Tablet 250mg exactly as prescribed by your doctor
• Swallow the tablet whole with a full glass of water
• Take with food or milk to reduce stomach upset
• Usual adult dose is one tablet every 6 to 8 hours as needed for pain
• Do not use for more than 7 days in a row unless your doctor advises otherwise
• Do not double the dose to make up for a missed one
• Use only the dose your doctor recommends for your condition

Drug Interactions

• Blood thinners (Warfarin): Mefenamic acid can increase the risk of bleeding when combined with anticoagulants.
• Aspirin and other NSAIDs: Combined use raises the risk of stomach ulcers and bleeding without added pain relief benefit.
• Blood pressure medicines: Mefenamic acid may reduce the effectiveness of ACE inhibitors, ARBs and diuretics and increase strain on the kidneys.
• Lithium: Can raise lithium levels in the blood, increasing the risk of toxicity.
• Methotrexate: May increase methotrexate levels and related toxicity.
• Corticosteroids: Combined use further increases the risk of stomach bleeding and ulcers.
• SSRIs (antidepressants): Taking together may raise the risk of bleeding, especially in the stomach.

Risks and warnings

• Cardiovascular risk: Long term or high dose use of NSAIDs like mefenamic acid may raise the risk of heart attack or stroke, especially in people with heart disease or its risk factors.
• Stomach and intestinal risk: Can cause stomach pain, ulcers or bleeding in the stomach or intestines, which may occur without warning signs, especially with longer use.
• Kidney caution: May reduce kidney function, particularly in older adults, people who are dehydrated, or those with existing kidney disease.
• Not for prolonged use: Doctors in Pakistan generally advise against using this tablet for more than 7 days at a stretch without medical supervision.
• Pregnancy caution: Should be avoided in the last trimester of pregnancy as it may affect the baby's heart and reduce amniotic fluid.
• Asthma and allergy caution: Avoid if you have a history of asthma, hives or allergic reactions triggered by aspirin or other NSAIDs.
• Bleeding risk: Use cautiously if you are on blood thinners or have a bleeding disorder.
• Liver caution: Use carefully in people with existing liver disease, as NSAIDs can affect liver function in rare cases.

Mefenamic Acid Tablet 250mg Side Effects

• Stomach upset or indigestion
• Nausea or vomiting
• Diarrhea or constipation
• Headache or dizziness
• Drowsiness
• Skin rash
• Fluid retention or mild swelling
• Stomach ulcers or bleeding with prolonged use
• Kidney function changes with long term use
• Rare allergic reactions such as difficulty breathing or facial swelling

Storage Conditions

• Store at room temperature, below 30°C
• Keep in a dry place away from direct sunlight and moisture
• Keep the tablets in their original blister pack until ready to use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack