About Oflobid Tablet 400mg
Ofloxacin 400mg tablet for severe bacterial infections in adults, once prescribed.
Oflobid Tablet 400mg Uses
- Complicated urinary tract infections
- Acute kidney infection (pyelonephritis)
- Chronic bacterial prostatitis
- Lower respiratory tract infections including bronchitis and pneumonia
- Skin and soft tissue infections
- Typhoid fever caused by Salmonella typhi
- Uncomplicated gonorrhea
Oflobid Tablet 400mg Benefits
- Broad spectrum action against many gram negative and some gram positive bacteria
- High oral absorption, works nearly as well as an injection
- Convenient once or twice daily dosing improves treatment compliance
- Useful option when standard first line antibiotics are not effective
- Reaches good concentration in urine, kidney tissue and lungs
What Experts Say
Ofloxacin belongs to the fluoroquinolone class of antibiotics. It works by blocking two bacterial enzymes, DNA gyrase and topoisomerase IV, which bacteria need to copy their genetic material. Without these enzymes, bacteria cannot multiply and eventually die off, clearing the infection from the body.
The 400mg strength is generally reserved for more severe or complicated infections, such as kidney infections, chronic prostatitis or resistant respiratory infections. Doctors often prefer this dose when lower strength options or standard first line antibiotics have already failed or are unsuitable for the patient.
Fluoroquinolones carry genuine safety concerns including tendon damage, nerve related side effects and heart rhythm changes. Doctors usually limit the treatment course to the shortest effective duration and monitor patients with existing heart, nerve or tendon conditions closely throughout therapy.
Drug Class
- Fluoroquinolone antibiotic
- Second generation quinolone
Oflobid Tablet 400mg Uses in Urdu
- پیشاب کی نالی کے شدید انفیکشن کے علاج میں
- گردے کے انفیکشن یعنی پائیلونیفرائٹس میں
- سانس کی نالی کے انفیکشن جیسے برونکائٹس اور نمونیا میں
- جلد اور نرم بافتوں کے انفیکشن میں
- ٹائیفائیڈ بخار کے علاج میں
- پروسٹیٹ کے دائمی بیکٹیریل انفیکشن میں
Oflobid Tablet 400mg formula
How to use Oflobid Tablet 400mg?
- Take Oflobid Tablet 400mg exactly as prescribed by your doctor, usually once or twice daily.
- Swallow the tablet whole with a full glass of water.
- Avoid taking with milk, yogurt or calcium fortified juices at the same time.
- Space each dose evenly through the day as directed by your doctor.
- Complete the full course even if symptoms improve early.
- Avoid antacids, iron or zinc supplements within 2 hours of taking this medicine.
- Drink plenty of water throughout the day while on this medicine.
Drug Interactions
- Antacids and Mineral Supplements: Aluminum, magnesium, calcium, iron and zinc products reduce absorption of ofloxacin, so separate dosing by at least 2 hours.
- Warfarin: May increase bleeding risk by enhancing the blood thinning effect of warfarin.
- NSAIDs: Combined use with painkillers like ibuprofen may increase the risk of seizures.
- Theophylline: Ofloxacin can raise theophylline blood levels, increasing the risk of toxicity.
- Antidiabetic Medicines: May cause significant blood sugar swings when combined with insulin or sulfonylureas.
- QT Prolonging Drugs: Combining with certain heart rhythm medicines raises the risk of dangerous heart rhythm changes.
Risks and warnings
- Tendon Damage: Ofloxacin can cause tendon inflammation and rupture, especially in the Achilles tendon, more common in people over 60 and those on steroid medicines.
- Heart Rhythm Changes: This medicine may prolong the QT interval and needs caution in people with heart rhythm problems or those taking other QT prolonging drugs.
- Nervous System Effects: Ofloxacin can cause dizziness, seizures, confusion, tremors and rarely nerve pain or numbness, especially in older adults.
- Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding unless clearly necessary, since fluoroquinolones can affect developing cartilage.
- Children and Teens: Generally avoided in growing children due to the risk of joint and cartilage damage.
- Myasthenia Gravis: Can worsen muscle weakness in people with this condition and should be avoided.
- Sun Sensitivity: May increase sensitivity to sunlight, leading to sunburn or skin rash.
Oflobid Tablet 400mg Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Trouble sleeping
- Abdominal pain
- Vomiting
- Vaginal itching or discharge in women
- Skin rash
- Tendon pain or swelling
- Increased sun sensitivity
- Restlessness or nervousness
Storage Conditions
- Store below 30 degrees Celsius in a cool dry place.
- Keep away from direct sunlight and moisture.
- Keep the tablets in their original blister pack until use.
- Keep out of reach of children.
- Do not use after the expiry date printed on the pack.
