About Sitaglu Met Tablet 50mg / 850mg
Sitaglu Met Tablet contains Sitagliptin and Metformin, used to manage type 2 diabetes in adults.
Sitaglu Met Tablet 50mg / 850mg Uses
- Type 2 diabetes mellitus, alone or combined with diet and exercise
- Blood sugar control when metformin alone is not enough
- Long term glycemic management in adults with type 2 diabetes
- Add on therapy for patients already stable on separate sitagliptin and metformin doses
Sitaglu Met Tablet 50mg / 850mg Benefits
- Combines two complementary mechanisms in a single tablet
- Improves adherence by reducing the number of daily tablets
- Helps lower fasting and post meal blood sugar levels
- May support weight neutrality compared to some other diabetes drugs
What Experts Say
Doctors across Pakistan often start this fixed dose combination once metformin alone no longer keeps fasting glucose within target range. Sitagliptin adds a complementary incretin based mechanism that raises insulin release only when blood sugar is high, so it rarely causes hypoglycemia when taken alone or with metformin.
Physicians recommend starting the lower metformin strength when renal function is borderline, then titrating upward gradually as tolerance allows. Regular kidney function and HbA1c checks help confirm the combination is working and that lactic acidosis risk stays low, especially in older or frail patients.
This combination suits adults who need more than one oral agent but want to avoid injectable therapy early on. Physicians weigh gastrointestinal tolerance, body weight, and cardiovascular history before choosing between this pairing and other second line diabetes options.
Drug Class
- Dipeptidyl Peptidase 4 (DPP-4) Inhibitor
- Biguanide
Sitaglu Met Tablet 50mg / 850mg Uses in Urdu
- ٹائپ ٹو ذیابیطس میں خون میں شکر کی سطح کو قابو میں رکھنے کے لیے استعمال ہوتی ہے۔
- جب اکیلی میٹفارمن سے شوگر کنٹرول نہ ہو تو معالج اسے تجویز کرتے ہیں۔
- خوراک اور ورزش کے ساتھ ملا کر بلڈ شوگر کو بہتر انداز میں سنبھالنے میں مدد دیتی ہے۔
- روزانہ کی گولیوں کی تعداد کم کر کے دوا کے استعمال کو آسان بناتی ہے۔
Sitaglu Met Tablet 50mg / 850mg formula
How to use Sitaglu Met Tablet 50mg / 850mg?
- Take with meals to reduce stomach upset
- Swallow the tablet whole with a full glass of water
- Take at the same times each day for steady blood sugar control
- Do not crush or split the tablet unless a doctor advises otherwise
- Continue diet and exercise changes alongside this medicine
- Do not double the dose if a tablet is missed, take the next dose as scheduled
Drug Interactions
- Sulfonylureas: Increases risk of hypoglycemia when combined, dose adjustment may be required.
- Insulin: Combined use raises low blood sugar risk and needs closer glucose monitoring.
- Iodinated Contrast Media: Can increase the risk of acute kidney injury and lactic acidosis when metformin is not paused around the procedure.
- Diuretics: May worsen kidney function and raise lactic acidosis risk with metformin.
- Corticosteroids: Can raise blood sugar and reduce the effectiveness of this combination.
- Alcohol: Increases lactic acidosis risk and can cause unpredictable blood sugar swings.
- Digoxin: Sitagliptin may slightly raise digoxin levels, monitoring is advised in patients on digoxin.
Risks and warnings
- Lactic Acidosis: Rare but serious risk from the metformin component, higher in patients with kidney or liver impairment, heavy alcohol use, or dehydration.
- Kidney Function: Requires periodic renal function tests before and during treatment since metformin is cleared by the kidneys.
- Contrast Dye Procedures: Temporarily stop before and after iodinated contrast imaging to avoid acute kidney injury.
- Pancreatitis: Stop the medicine and seek care if severe abdominal pain, nausea, or vomiting develops.
- Hypoglycemia With Other Drugs: Risk rises when combined with sulfonylureas or insulin, dose adjustment may be needed.
- Pregnancy And Breastfeeding: Use only if a doctor confirms it is necessary, insulin is usually preferred during pregnancy.
Sitaglu Met Tablet 50mg / 850mg Side Effects
- Nausea or upset stomach
- Diarrhea or loose stools
- Abdominal discomfort or bloating
- Headache
- Metallic taste in the mouth
- Reduced appetite
- Upper respiratory tract symptoms
- Low blood sugar when combined with other diabetes drugs
- Vitamin B12 deficiency with long term use
- Rare allergic skin reactions
- Rare pancreatitis symptoms such as severe stomach pain
- Rare signs of lactic acidosis such as unusual tiredness or difficulty breathing
Storage Conditions
- Store below 30 degrees Celsius in a cool, dry place
- Keep the blister strip in its original box away from direct sunlight
- Protect from moisture and do not store in the bathroom
- Keep out of reach of children
- Do not use after the printed expiry date
