Spasrid Tablet

About Spasrid Tablet

Spasrid Tablet Uses

• Relief of smooth muscle spasms and cramps in the gastrointestinal tract.
• Management of functional bowel disorders and irritable bowel syndrome symptoms.
• Treatment of biliary colic and spasmodic abdominal pain.
• Relief of dysmenorrhea and menstrual cramps.
• Management of urinary tract spasms and ureterolithiasis pain.

Spasrid Tablet Benefits

• Direct musculotropic action on smooth muscle bypassing cholinergic pathways.
• Effective smooth muscle relaxation independent of the autonomic nervous system.
• Avoids anticholinergic side effects of dry mouth, blurred vision, and urinary retention.
• Rapid onset of action providing quick relief from spasmodic pain.
• Well-tolerated in a broad range of patients including those with contraindications to anticholinergics.

What Experts Say

Phloroglucinol and trimethylphloroglucinol are musculotropic antispasmodic agents that act directly on smooth muscle cells rather than on the autonomic nervous system. Unlike anticholinergic agents these compounds exert their effect by interfering with intracellular mechanisms controlling smooth muscle contraction. They reduce the contractile activity of muscle fibres allowing spasming muscle to relax. This direct action on smooth muscle is independent of the cholinergic or adrenergic nervous system making the drugs effective regardless of the neurological cause of spasm.

Pharmacokinetically, phloroglucinol and trimethylphloroglucinol demonstrate rapid oral absorption with onset of action within 30 to 60 minutes. Peak plasma concentrations occur within 1 to 2 hours. The duration of action ranges from 4 to 6 hours allowing three-times-daily dosing. Both compounds undergo hepatic metabolism with renal excretion of metabolites. The direct action on smooth muscle produces localized effects in the gastrointestinal and biliary tracts with minimal systemic absorption.

Clinical efficacy studies demonstrate spasrid effectively relieves smooth muscle spasm associated with functional bowel disorders and irritable bowel syndrome. The drug provides rapid symptomatic relief superior to placebo in biliary colic and menstrual cramp management. The direct muscle relaxant mechanism proves particularly valuable in patients who cannot tolerate anticholinergic side effects. Long-term tolerability is excellent with minimal adverse effects. Patient satisfaction remains high due to rapid onset and lack of anticholinergic complications.

Drug Class

• Musculotropic Antispasmodic, Direct Smooth Muscle Relaxant

Packaging and Quantity

• Blister strip containing 10 tablets of 40 mg phloroglucinol and 0.04 mg trimethylphloroglucinol each.

When Not to Use Spasrid

• Known hypersensitivity to phloroglucinol or trimethylphloroglucinol.
• Functional bowel paralysis or intestinal obstruction.
• Prostatic enlargement.
• Myasthenia gravis.
• Angle-closure glaucoma.
• Pregnancy and breastfeeding.

Spasrid Tablet formula

• Phloroglucinol
• Trimethylphloroglucinol

Available forms

• Tablets
• Injection

How to use Spasrid Tablet?

• Take orally three times daily as directed by your healthcare provider.
• Typical adult dose is one tablet three times daily with a maximum of 6 tablets daily.
• Swallow tablet whole with a full glass of water.
• Can be taken with or without food.
• Do not crush or chew the tablet.
• Take at regular intervals for consistent symptom relief.

Contraindications

The use of Sparsid tablet is contraindicated in the following conditions:

• Myasthenia Gravis
• Coma
• Iodine sensitivity
• Unconsciousness
• Paralytic ileus
• Pyloric stenosis
• Acute coloinc distension
• Prostatic enlargement

Drug Interactions

Spasrid may interact with various medications affecting safety or efficacy:

• Other antispasmodic medications: Concurrent use may cause excessive smooth muscle relaxation; avoid combination or monitor closely.
• Anticholinergic medications: Use with caution as additive effects may increase anticholinergic side effects.
• Sedatives or CNS depressants: May potentiate sedative effects; exercise caution with concurrent use.
• Tricyclic antidepressants: May have additive anticholinergic effects; monitor for side effects.

Risks and warnings

• Pregnancy: Contraindicated throughout pregnancy due to risk of uterine contractions and fetal harm.
• Breastfeeding: Contraindicated during breastfeeding as drug passes into breast milk.
• Cardiac conditions: Use with caution in patients with cardiac disease; monitor heart rate and rhythm.
• Glaucoma: Contraindicated in angle-closure glaucoma; use cautiously in open-angle glaucoma.
• Liver and kidney disease: Use with caution in significant hepatic or renal impairment; dose adjustment may be needed.
• Elderly patients: Increased sensitivity to side effects; monitor closely and consider dose reduction.
• Driving and machinery: Avoid if dizziness occurs; do not operate heavy machinery until effects are known.

Spasrid Tablet Side Effects

Most side effects are mild and transient. Following are commonly reported adverse effects:

• Nausea or vomiting.
• Diarrhea or constipation.
• Headache or dizziness.
• Flushing or dry mouth.
• Weakness or fatigue.

Serious side effects requiring immediate medical attention:

• Severe allergic reaction with rash or angioedema.
• Severe bradycardia or cardiac arrhythmias.
• Difficulty breathing or bronchospasm.
• Acute angle-closure glaucoma.

Storage Conditions

• Store at room temperature below 30 degrees Celsius.
• Keep away from direct sunlight and excessive heat.
• Protect from moisture in a tightly sealed container.
• Keep in original blister strip or tablet container.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the packaging.