Xavor Tablet 50mg

About Xavor Tablet 50mg

Xavor Tablet Uses

• Management of hypertension including essential hypertension.
• Reduction of cardiovascular risk in patients with hypertension and left ventricular hypertrophy.
• Prevention of stroke and myocardial infarction in high-risk hypertensive patients.
• Renal protection in patients with type 2 diabetes and albuminuria or proteinuria.
• Post-myocardial infarction heart failure management in hemodynamically stable patients.

Xavor Tablet Benefits

• Selective angiotensin II receptor blockade provides effective blood pressure reduction.
• Reduces left ventricular hypertrophy and remodeling improving cardiac function.
• Protects kidneys from damage in diabetic nephropathy.
• Reduces cardiovascular events including stroke and heart attack in high-risk patients.
• Well-tolerated with favorable side effect profile compared to ACE inhibitors.

What Experts Say

Losartan is an angiotensin II receptor blocker that selectively blocks the binding of angiotensin II to AT1 receptors in vascular smooth muscle and adrenal tissue. This blockade prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II leading to peripheral vasodilation and reduced vascular resistance. The resulting decrease in blood pressure is accompanied by reduced sodium reabsorption and increased sodium and water excretion. Losartan is structurally distinct from ACE inhibitors and does not induce bradykinin potentiation.

Pharmacokinetically, losartan demonstrates good oral bioavailability with peak plasma concentrations occurring within 1 to 2 hours. The drug undergoes rapid first-pass metabolism via the liver producing an active metabolite (EXP-3174) that is more potent than the parent compound. The active metabolite has a half-life of 6 to 9 hours enabling effective once-daily dosing. Elimination occurs primarily via renal and biliary excretion. Steady-state concentrations are achieved within 3 to 5 days of consistent dosing.

Clinical efficacy data demonstrates that losartan effectively reduces systolic and diastolic blood pressure with superior renal protective effects in diabetic patients. Large outcome trials show losartan reduces cardiovascular mortality and heart failure hospitalizations in post-myocardial infarction patients. The drug reduces left ventricular hypertrophy more effectively than placebo and produces effects comparable to ACE inhibitors. Long-term follow-up data supports sustained antihypertensive efficacy and tolerability with minimal dose adjustment requirements.

Drug Class

• Angiotensin II Receptor Blocker (ARB)

Packaging and Quantity

• Blister strip containing 10 tablets of 100 mg each or 20 tablets of 50 mg or 25 mg each.

When Not to Use Xavor

• Known hypersensitivity to losartan or other ARB medications.
• Pregnancy especially in second and third trimester.
• Severe hepatic impairment or cirrhosis.
• Hyperkalemia or history of elevated serum potassium.
• Concurrent use with aliskiren in diabetic patients.

Xavor Tablet 50mg formula

• Losartan Potassium

Available forms

• Tablets

How to use Xavor Tablet 50mg?

• Take orally once daily as directed by your healthcare provider.
• Typical starting dose for hypertension is 25 to 50 mg once daily.
• Usual maintenance dose ranges from 25 to 100 mg once daily.
• Swallow tablet whole with a full glass of water.
• Can be taken with or without food.
• Continue taking regularly even if blood pressure is controlled.

Drug Interactions

Xavor may interact with various medications affecting efficacy or safety:

• ACE inhibitors: Combined use increases hyperkalemia risk and may reduce effectiveness; avoid combination.
• Potassium supplements and potassium-sparing diuretics: May increase serum potassium levels; monitor K+ levels closely.
• NSAIDs: May reduce antihypertensive efficacy and increase renal dysfunction risk.
• Lithium: Losartan may increase lithium levels; monitor lithium concentrations.
• Thiazide diuretics: Combined use has additive antihypertensive effects; may require dose adjustment.

Risks and warnings

• Pregnancy: Contraindicated especially in second and third trimester due to fetal renal dysfunction risk.
• Renal impairment: Use with caution in severe renal disease; may require dose adjustment.
• Hyperkalemia: Monitor serum potassium regularly especially in renal disease or when used with potassium-elevating drugs.
• Hypotension: May cause significant blood pressure reduction especially in volume-depleted patients.
• Hepatic disease: Severe hepatic impairment may increase losartan exposure; dose adjustment may be needed.
• Breastfeeding: Losartan passes into breast milk; use with caution during lactation.
• Alcohol interaction: Alcohol may increase hypotensive effects; limit alcohol consumption.

Xavor Tablet Side Effects

Most side effects are mild and transient with continued use. Following are commonly reported adverse effects:

• Dizziness or lightheadedness.
• Fatigue or weakness.
• Cough.
• Headache.
• Hyperkalemia causing muscle weakness or palpitations.

Serious side effects requiring immediate medical attention:

• Severe allergic reaction with angioedema.
• Syncope or severe hypotension.
• Acute renal failure or significant renal dysfunction.
• Severe hyperkalemia with cardiac arrhythmias.

Storage Conditions

• Store at room temperature between 15 to 25 degrees Celsius.
• Keep away from direct sunlight and excessive heat.
• Protect from moisture in a tightly sealed container.
• Keep in original blister strip or tablet container.
• Keep out of reach of children and pets.
• Do not use after the expiration date on the packaging.