Cefiget Capsule 400mg

About Cefiget Capsule 400mg

Cefiget Tablet Uses

• Urinary tract infections caused by susceptible bacteria.
• Respiratory tract infections such as bronchitis and pneumonia.
• Typhoid fever caused by Salmonella typhi.
• Middle ear infections (otitis media), particularly in children.
• Uncomplicated gonorrhea.
• Skin and soft tissue infections caused by susceptible bacteria.

Cefiget Tablet Benefits

• Effective against a broad range of gram positive and gram negative bacteria.
• Convenient once or twice daily dosing compared to antibiotics requiring more frequent doses.
• Well suited for typhoid fever, a common indication in this region.
• Available as a tablet, capsule, and suspension, allowing dosing flexibility across age groups.
• Reasonable alternative for patients with a documented penicillin allergy, under a doctor's guidance.
• Widely used third-generation cephalosporin with an established safety record.

What Experts Say

Cefiget contains Cefixime, a third-generation cephalosporin antibiotic that binds to penicillin-binding proteins on the bacterial cell wall. This blocks the final step of peptidoglycan synthesis, the process that builds and maintains the bacterial cell wall, causing the wall to weaken until the bacterial cell ruptures and dies.

As a third-generation cephalosporin, Cefixime covers a broad range of gram negative bacteria more effectively than earlier cephalosporin generations, which is part of why it is commonly used for typhoid fever in regions where Salmonella typhi remains a frequent cause of prolonged fever.

Cefixime is absorbed from the gut and cleared mainly through the kidneys, with a portion excreted unchanged in urine. Antacids and iron supplements can bind to Cefixime in the gut and reduce how much is absorbed, which is why timing matters when other medicines are taken alongside it.

Drug Class

• Third-Generation Cephalosporin Antibiotic

Packaging and Quantity

• Pack of 10 tablets.

When Not to Use Cefiget

• Known allergy or hypersensitivity to Cefixime or other cephalosporin antibiotics.
• A history of severe allergic reaction to Penicillin, since cross reactivity can occur in a small number of patients.
• Severe kidney impairment, unless the dose has been adjusted by a doctor.
• A history of gastrointestinal disease, particularly colitis linked to previous antibiotic use.

Cefiget Capsule 400mg formula

• Cefixime

Available forms

• Tablets
• Capsules
• Suspension

How to use Cefiget Capsule 400mg?

• Cefiget may be taken with or without food.
• The tablet should be swallowed whole with a glass of water.
• Antacids and iron supplements should be avoided within two hours of taking Cefiget, since they can reduce its absorption.
• Plenty of fluids should be taken throughout the course, especially in hot weather.
• The full course should be completed exactly as prescribed, even if symptoms improve before it is finished.
• The dose should not be increased or the course extended beyond what a doctor has recommended.

Drug Interactions

Cefixime has a few notable interactions, mostly related to absorption and clearance. The following should be noted:

• Antacids and Iron Supplements: Taking these within two hours of Cefiget can reduce how much is absorbed, lowering its effectiveness.
• Warfarin: Cefiget may increase Warfarin's blood thinning effect, raising the risk of bleeding.
• Probenecid: This medicine slows the clearance of Cefixime through the kidneys, raising its blood levels.
• Carbamazepine: Cefiget may increase Carbamazepine blood levels, raising the risk of side effects.

Risks and warnings

• Penicillin allergy: Patients with a severe penicillin allergy have a small but real chance of also reacting to Cefiget.
• Gastrointestinal infection risk: Antibiotic use, including Cefiget, can occasionally lead to a bowel infection that causes severe diarrhea.
• Kidney disease: Dose adjustment is needed in patients with significant kidney impairment.
• Prolonged or repeated use: Using Cefiget when it is not needed, or not completing the full course, contributes to antibiotic resistance.
• Pregnancy: Cefiget should only be used during pregnancy when clearly needed and directed by a doctor.
• Breastfeeding: Cefixime passes into breast milk in small amounts, so a doctor should be consulted before use while nursing.
• Children: Dosing in children should always be based on their weight and confirmed by a doctor.

Cefiget Tablet Side Effects

Loose stools and stomach upset are the effects most often reported with Cefixime, alongside:

• Diarrhea.
• Nausea.
• Abdominal pain.
• Headache.

Effects that call for prompt medical attention are less common but include:

• Severe, watery diarrhea that does not improve, which may indicate a bowel infection.
• Severe allergic reaction including facial swelling or difficulty breathing.
• Widespread skin rash or blistering.

Storage Conditions

• Store at room temperature, below 30°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original packaging until ready to use.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the packaging.
• Do not store in the bathroom or near a kitchen sink.