About Clotnil Plus Tablet 75mg / 75mg
A dual action tablet that lowers the risk of heart attack and stroke in high risk patients.
Clotnil Plus Tablet Uses
- Secondary prevention after a heart attack
- Secondary prevention after an ischemic stroke or mini stroke
- Dual antiplatelet therapy after a coronary stent procedure
- Management of unstable angina
Clotnil Plus Tablet Benefits
- Clot prevention through two separate pathways for stronger protection
- Lower risk of a second heart attack or stroke
- Supports long term stent patency after angioplasty
What Experts Say
Aspirin and clopidogrel work through two separate pathways to stop platelets from clumping together. Aspirin blocks an enzyme called COX-1, while clopidogrel blocks the P2Y12 receptor on the platelet surface. Using both together gives stronger clot prevention than either drug alone.
Pakistani cardiologists commonly prescribe this combination for six to twelve months after a heart attack or after a coronary stent is placed, since this window carries the highest risk of stent related clotting. The exact duration depends on the type of stent and the patient's individual bleeding risk.
Doctors usually assess bleeding risk before starting therapy and ask patients to stop the combination several days before any planned surgery. Some patients respond less well to clopidogrel due to genetic differences in how the liver activates the drug, which doctors keep in mind when a patient does not respond as expected.
Drug Class
Clotnil Plus Tablet 75mg / 75mg Uses in Urdu
- دل کے دورے سے بچاؤ
- فالج کی روک تھام
- خون کے لوتھڑے بننے سے روکنا
- انجائنا کے مریضوں میں استعمال
Clotnil Plus Tablet 75mg / 75mg formula
- Aspirin 75mg + Clopidogrel Bisulphate 75mg
How to use Clotnil Plus Tablet 75mg / 75mg?
- This tablet is usually taken once daily at the same time, as advised by the treating doctor.
- A meal alongside the dose can reduce stomach discomfort in sensitive patients.
- The tablet is swallowed whole with water, without crushing or splitting it.
- This medicine is not stopped suddenly without medical advice, since early stopping can raise clotting risk.
- Any planned surgery or dental procedure is discussed with the doctor in advance, since the dose may need to be paused.
Drug Interactions
- Warfarin And Anticoagulants: Combining these drugs with Clotnil Plus significantly raises the risk of serious bleeding.
- NSAIDs: Regular pain relievers like ibuprofen or diclofenac add to the stomach bleeding risk when combined with this medicine.
- Omeprazole: This proton pump inhibitor may reduce how well clopidogrel is activated in the body, lowering its effect.
- SSRIs: Antidepressants from the SSRI class can add to the bleeding risk when taken alongside this medicine.
- Methotrexate: Aspirin in this combination can raise methotrexate levels in the blood, increasing toxicity risk.
Risks and warnings
- Bleeding Risk: This combination raises the chance of bleeding, including bruising, nosebleeds, and in rare cases serious internal bleeding.
- Stomach Ulcer: Long term use can irritate the stomach lining and raise the risk of ulcers or gastrointestinal bleeding.
- Surgery Precaution: This medicine is usually paused before planned surgery or dental work, on the doctor's advice, to reduce bleeding risk.
- Blood Disorder: A rare blood clotting disorder called thrombotic thrombocytopenic purpura has been linked to clopidogrel use.
- Sudden Stoppage: Stopping this medicine suddenly, especially soon after a stent procedure, can raise the risk of a new clot.
Clotnil Plus Tablet Side Effects
- Easy bruising
- Nosebleeds
- Upset stomach or heartburn
- Nausea
- Diarrhea or constipation
- Skin rash
- Rare serious gastrointestinal bleeding
- Rare bleeding inside the skull
- Rare blood clotting disorder called thrombotic thrombocytopenic purpura
Storage Conditions
- Store below 25°C in a dry place away from direct heat.
- Keep the blister strip sealed until the tablet is needed.
- Protect from moisture and excess humidity.
- Keep out of reach of children at all times.
