Corinef Capsule 400mg

About Corinef Capsule 400mg

Corinef Capsule 400mg Uses

• Throat and tonsil infections
• Middle ear infections
• Acute bronchitis and lower respiratory infections
• Urinary tract infections
• Typhoid fever caused by susceptible Salmonella strains
• Gonorrhea caused by susceptible bacteria

Corinef Capsule 400mg Benefits

• Once daily dosing suitable for adult patients
• Effective against a broad range of gram negative bacteria
• Stable oral absorption that is not significantly affected by food
• Convenient alternative to injectable cephalosporins for outpatient treatment

What Experts Say

Doctors across Pakistan often prescribe Cefixime for typhoid fever, since it remains active against many Salmonella strains that have grown resistant to older antibiotics. The 400mg adult capsule strength allows once daily dosing, which supports better completion of the full treatment course.

Physicians favor third generation cephalosporins like Cefixime when a patient needs broad gram negative coverage but cannot tolerate an injectable antibiotic. Kidney function is checked before prescribing in patients with existing kidney disease, since the dose usually needs to be reduced when kidney clearance is moderately to severely impaired.

Clinicians caution that Cefixime does not reliably cover certain resistant organisms, so a culture and sensitivity test is recommended for infections that fail to improve within 48 to 72 hours of starting treatment. Patients with a documented penicillin allergy are monitored closely due to possible cross reactivity with cephalosporins.

Drug Class

• Third generation cephalosporin antibiotic
• Beta-lactam antibiotic

Corinef Capsule 400mg formula

• Cefixime

Available forms

• Capsule

How to use Corinef Capsule 400mg?

• Take one capsule by mouth once daily or as directed by the doctor
• Swallow the capsule whole with a glass of water
• Can be taken with or without food
• Complete the full course even if symptoms improve early
• Take at the same time each day for consistent blood levels

Drug Interactions

• Warfarin: May increase the blood thinning effect and raise the risk of bleeding
• Carbamazepine: Blood levels of carbamazepine may rise when taken together with Cefixime
• Probenecid: Increases Cefixime blood levels by slowing its elimination from the body
• Oral Contraceptives: May reduce the effectiveness of hormonal birth control
• Antacids: May slightly reduce the rate of absorption when taken at the same time

Risks and warnings

• Penicillin Allergy: Use with caution in patients with a known penicillin allergy due to possible cross reactivity
• Kidney Disease: Dose adjustment needed in patients with reduced kidney function
• Colitis Risk: May cause severe diarrhea due to Clostridioides difficile overgrowth, requiring prompt medical attention
• Seizure Disorders: Use cautiously in patients with a history of seizures
• Pregnancy and Breastfeeding: Use only if clearly needed and under medical supervision

Corinef Capsule 400mg Side Effects

• Diarrhea
• Nausea
• Abdominal pain
• Headache
• Dizziness
• Skin rash
• Vaginal itching or yeast infection
• Elevated liver enzymes
• Loss of appetite

Storage Conditions

• Store below 30°C in a dry place away from moisture and direct sunlight
• Keep capsules in their original blister pack until ready to use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack