Covance Tablet 10 / 160mg

About Covance Tablet 10 / 160mg

Covance Tablet Uses

• Treats high blood pressure (hypertension)
• Used for long term blood pressure control when a single medicine is not enough
• Helps reduce the risk of stroke and heart attack linked to high blood pressure
• May be used to manage chronic stable angina in some cases

Covance Tablet Benefits

• Combines two blood pressure lowering mechanisms in a single tablet
• Once daily dosing supports better treatment adherence
• Reduces the strain on the heart and blood vessels over time
• Can allow lower individual doses of each drug, reducing side effects

What Experts Say

Amlodipine is a calcium channel blocker that relaxes the smooth muscle in blood vessel walls, widening the vessels and lowering resistance to blood flow. Valsartan is an angiotensin receptor blocker that stops a hormone called angiotensin II from narrowing blood vessels and raising blood pressure.

Combining the two drugs targets blood pressure through separate pathways, which often produces a greater reduction than either drug alone at a similar dose. This combination approach is commonly used when blood pressure remains high despite treatment with a single agent.

Because the two mechanisms work independently, side effects tied to high doses of either single drug, such as ankle swelling from amlodipine, can sometimes be reduced when both agents are used together at moderate doses. Regular blood pressure and kidney function monitoring is still recommended during treatment.

Drug Class

• Calcium Channel Blocker
• Angiotensin Receptor Blocker (ARB)

Covance Tablet 10 / 160mg formula

• Amlodipine + Valsartan

Available forms

• Tablet (10mg/160mg)

How to use Covance Tablet 10 / 160mg?

• Take one tablet daily at the same time each day.
• Swallow the tablet whole with a glass of water.
• Take with or without food, based on doctor's advice.
• Do not stop the medicine suddenly without consulting a doctor.
• Monitor blood pressure regularly during treatment.

Drug Interactions

• Potassium Sparing Diuretics: Combined use can raise blood potassium to dangerous levels.
• NSAIDs: Regular use of pain relievers like ibuprofen may reduce the blood pressure lowering effect and affect kidney function.
• Other Blood Pressure Medicines: Combining with additional antihypertensives can increase the risk of excessively low blood pressure.
• Lithium: May increase lithium levels in the blood, raising the risk of toxicity.

Risks and warnings

• Pregnancy: Avoid use during pregnancy, as drugs acting on the renin angiotensin system can harm the developing fetus.
• Kidney Disease: Use with caution in people with reduced kidney function, and monitor kidney tests regularly.
• Liver Disease: Dose adjustment may be needed in people with significant liver impairment.
• Low Blood Pressure: May cause dizziness or fainting, especially after the first few doses.
• Potassium Levels: Can raise blood potassium, so avoid potassium supplements unless advised by a doctor.

Covance Tablet 10/160mg Side Effects

• Dizziness or lightheadedness
• Swelling in the ankles or feet
• Headache
• Fatigue
• Flushing
• Low blood pressure
• Elevated potassium levels on lab tests

Storage Conditions

• Store below 30°C in a cool, dry place.
• Keep away from direct sunlight and moisture.
• Keep out of reach of children.
• Discard any unused tablets after the expiry date.