About Isotrate Tablet 10mg
Isotrate 10mg is isosorbide mononitrate, a long acting nitrate used as a starting dose to prevent angina.
Isotrate Tablet 10mg Uses
- Prevention of angina (chest pain) episodes in coronary artery disease
- Starting dose when beginning long term nitrate therapy
- Ongoing prevention in patients who respond well to a lower strength
- Use in elderly or sensitive patients who need a gentler nitrate dose
Isotrate Tablet 10mg Benefits
- Widens blood vessels to improve blood flow to the heart muscle
- Lowers the heart's oxygen demand during physical activity
- Allows a gradual, better tolerated introduction to nitrate treatment
- Suitable lower strength for patients sensitive to blood pressure drops
What Experts Say
Isosorbide mononitrate belongs to a family of long acting organic nitrates that release nitric oxide once absorbed into the bloodstream. Unlike isosorbide dinitrate, it does not need to be broken down by the liver first, so its effect on blood vessel width is more predictable from one dose to the next and less likely to vary between patients.
A 10mg strength is commonly the starting point when a doctor introduces long term nitrate treatment for angina, since it lets the body adjust gradually to the drop in blood pressure before moving to a higher maintenance dose. It also suits older patients, those with a smaller body frame, or anyone who reports marked dizziness on standing.
Like every nitrate strength, this dose still carries the same core safety rules. It should never be combined with erectile dysfunction medicines such as sildenafil or tadalafil, and doses need to be spaced correctly each day so the body does not build tolerance and lose the protective effect over time.
Drug Class
- Organic Nitrate
- Antianginal Agent
- Vasodilator
Isotrate Tablet 10mg Uses in Urdu
- سینے کے درد یعنی انجائنا سے بچاؤ کے لیے ابتدائی خوراک کے طور پر استعمال ہوتا ہے
- دل کی شریانوں کو کشادہ کر کے خون کی روانی بہتر بناتا ہے
- نائٹریٹ علاج کا آغاز کرنے والے مریضوں کے لیے موزوں مقدار ہے
- بزرگ یا حساس مریضوں میں کم مقدار میں تجویز کیا جاتا ہے
Isotrate Tablet 10mg formula
How to use Isotrate Tablet 10mg?
- Swallow the tablet whole with water, preferably on an empty stomach
- Take the two daily doses about seven hours apart to maintain a nitrate free interval overnight
- Do not crush or chew the tablet
- Follow this starting strength closely before any increase to a higher dose
- Do not stop the medicine suddenly without medical advice
- Keep a fast acting sublingual nitrate available for sudden chest pain, since this tablet works too slowly for emergencies
Drug Interactions
- PDE5 Inhibitors: Sildenafil, tadalafil and vardenafil must not be used with this medicine due to severe hypotension risk
- Riociguat: Contraindicated together because of additive blood pressure lowering
- Alcohol: Raises the chance of dizziness and low blood pressure
- Other Blood Pressure Medicines: Beta blockers, calcium channel blockers and diuretics can add to the blood pressure drop
- Aspirin: May increase nitrate levels slightly, watch for stronger side effects
Risks and warnings
- PDE5 Inhibitor Use: Combining with sildenafil, tadalafil or vardenafil can cause a severe and dangerous drop in blood pressure even at this lower strength
- Low Blood Pressure: Start cautiously in patients who already run low blood pressure or are dehydrated
- Sudden Discontinuation: Stopping abruptly can allow angina symptoms to return
- Elderly Patients: Older adults may need this lower strength first due to higher sensitivity to blood pressure drops
- Severe Anemia: Avoid in patients with significant anemia
- Driving And Machinery: May cause dizziness during the first days of treatment
- Pregnancy And Breastfeeding: Use only if the treating doctor considers it clearly necessary
Isotrate Tablet 10mg Side Effects
- Headache, common when treatment is first started
- Dizziness or lightheadedness on standing
- Flushing in the face or neck
- Mild drop in blood pressure
- Fast heartbeat
- Nausea
- General weakness
- Fainting, more likely if the dose is increased too quickly
- Return of chest pain if the medicine is stopped suddenly
- Skin rash in sensitive individuals
Storage Conditions
- Leave tablets sealed in the strip until the dose is due
- Keep the pack somewhere cool and dry, ideally below 30 degrees Celsius
- Protect from direct sunlight and avoid storing near a stove or heater
- Store out of the reach of children
- Do not use tablets beyond the expiry date printed on the strip
