Ivaset Tablet 5mg

About Ivaset Tablet 5mg

Ivaset Tablet 5mg Uses

• Chronic heart failure with reduced ejection fraction
• Stable angina pectoris (chest pain from reduced blood flow to the heart)
• Used when beta blockers are not tolerated or are contraindicated
• Helps lower resting heart rate in patients with normal sinus rhythm

Ivaset Tablet 5mg Benefits

• Reduces hospital admissions related to worsening heart failure
• Slows heart rate without significantly lowering blood pressure
• Can be combined with standard heart failure medications
• Improves exercise tolerance in stable angina patients
• Does not affect the heart's pumping strength (contractility)

What Experts Say

Doctors recommend ivabradine when the resting heart rate stays above 70 beats per minute despite optimal heart failure therapy. Physicians across Pakistan use it as an add on to standard treatment rather than a replacement for beta blockers, ACE inhibitors, or mineralocorticoid antagonists.

Physicians monitor heart rate closely during dose titration since bradycardia below 50 beats per minute requires dose reduction or discontinuation. Patients with visual disturbances, known as phosphenes, are advised these effects are usually mild and reversible after stopping the medicine.

Ivabradine selectively blocks the If current in the heart's sinoatrial node, slowing the rate of spontaneous depolarization without affecting conduction or contractility elsewhere in the heart. This selective action distinguishes it from beta blockers, which lower heart rate through broader receptor blockade.

Drug Class

• If Channel Inhibitor (Cardiac Pacemaker Current Inhibitor)
• Heart Rate Lowering Agent
• Anti-anginal Agent

Ivaset Tablet 5mg formula

• Ivabradine

Available forms

• Tablet

How to use Ivaset Tablet 5mg?

• Take by mouth with food to improve absorption
• Usual starting dose is 5mg twice daily, morning and evening
• Dose may be adjusted by the doctor based on heart rate response
• Swallow the tablet whole with a glass of water
• Do not stop taking suddenly without consulting your doctor
• Take at the same times each day for consistent heart rate control

Drug Interactions

• Ketoconazole and Itraconazole: Strong CYP3A4 inhibitors that significantly raise ivabradine blood levels; combined use is contraindicated.
• Diltiazem and Verapamil: Increase ivabradine exposure with an additive heart rate lowering effect; combined use is not recommended.
• Clarithromycin and Erythromycin: Macrolide antibiotics that can raise ivabradine levels through CYP3A4 inhibition.
• Rifampicin: A strong CYP3A4 inducer that may reduce ivabradine's effectiveness.
• QT Prolonging Drugs: Combined use with certain antiarrhythmic drugs may increase the risk of heart rhythm disturbances.

Risks and warnings

• Bradycardia: Can cause excessively slow heart rate, especially when combined with other rate-lowering medicines.
• Liver Impairment: Not recommended in patients with severe liver disease due to limited safety data.
• Visual Disturbances: May cause temporary brightness in the visual field known as phosphenes, particularly in the first two months.
• Atrial Fibrillation: Increases the risk of developing this irregular heart rhythm during treatment.
• Pregnancy: Not recommended as it may harm the developing baby; effective contraception is advised for women of childbearing age.

Ivaset Tablet 5mg Side Effects

• Luminous visual phenomena (temporary brightness in vision)
• Slow heart rate (bradycardia)
• Headache
• Dizziness
• Blurred vision
• High blood pressure
• Irregular heartbeat
• Palpitations
• Nausea
• Shortness of breath

Storage Conditions

• Store below 30°C in a cool, dry place away from moisture
• Keep the tablets in their original blister pack until ready to use
• Protect from direct sunlight
• Keep out of reach of children
• Do not use after the expiry date printed on the pack